Dr. Arsalan was involved in drug delivery to cancer cells during his PhD.
He, specifically, focused his research on the surface engineering of
polymeric nanoparticles to induce certain characteristics in these drug
delivery systems e.g. stealthy, targeting and stimuli responsiveness.
Moreover, he also worked on bio-imaging, and fabricated nanoparticles for
magnetic resonance imaging of cancer. His current research projects
Targeted Photothermal Therapy of localized Staph Infections
Staph infections, caused by Staphylococcus aureus, tend to infect
the skin or through the bloodstream almost any site in the body,
particularly heart valves and bones. The bacteria also tend to accumulate
on medical devices in the body e.g. artificial heart valves, pacemakers,
and catheters. Unluckily, many strains have developed resistance to the
effects of antibiotics. The inevitable growth of multi-drug resistant
bacteria has led to a major research effort to utilize alternative
antibacterial therapeutics such as Photothermal therapy. It involves the
use of photosensitizers in combination with visible light to produce heat
that could kill pathogenic microorganisms. However, the precise
accumulation of photosensitizer at infected site is still challenging. A
new approach is developed to produce temperature induced localization of
photosensitizer in staph infections.
Site-specific degradable stealthy nanoparticles for cancer treatment
The main reason of poor efficacy and adverse side effects of anticancer
drugs is their non-specific distribution. Stealthy nanoparticles are
employed to lessen non-specific distribution of drug. However, they hinder
in specific interaction with tumor. Contrarily, targeting nanoparticles
have been developed to enhance the interaction between nanoparticles and
cancer cells. But, they are more vulnerable to non-specific distribution.
The idea is to develop nanoparticles with stealthy layer; this layer
protects nanoparticles from non-specific distribution, when nanoparticles
arrive at cancer site, this layer is degraded due to cancer acidic
environment and site-specific targeting layer is uncovered for binding to
Natural materials based composite matrix: an effective wound dressing
for controlling hemorrhage and bacterial activities
This project is focused to develop chitosan based wound dressing with
enhanced hemorrhage controlling and bacterial characteristics. For this,
composite matrix, composed of three natural biomaterials, will be prepared.
These three components possess distinct characteristics i.e. they have
wound healing and film forming properties, strong adsorption tendency for
bacterial stains and toxins, and antimicrobial property especially against
bacterial infections. The interactions between different components and
synergistic effect of matrix will be evaluated. Moreover, the
microstructure of wound dressing will be designed in a way to mimic
extracellular matrix of tissues.