Dr. Arsalan Ahmed Ansari
Assistant Professor, IRCBM
Area of Interest: Polymeric Nanoparticles, Wound Dressing, Bio-imaging, Drug Delivery, Photo-thermal therapy, Tissue Engineering
Tel # (Off): 111-001-007   (891)

Dr. Arsalan was involved in drug delivery to cancer cells during his PhD. He, specifically, focused his research on the surface engineering of polymeric nanoparticles to induce certain characteristics in these drug delivery systems e.g. stealthy, targeting and stimuli responsiveness. Moreover, he also worked on bio-imaging, and fabricated nanoparticles for magnetic resonance imaging of cancer. His current research projects include:

Targeted Photothermal Therapy of localized Staph Infections
Staph infections, caused by Staphylococcus aureus, tend to infect the skin or through the bloodstream almost any site in the body, particularly heart valves and bones. The bacteria also tend to accumulate on medical devices in the body e.g. artificial heart valves, pacemakers, and catheters. Unluckily, many strains have developed resistance to the effects of antibiotics. The inevitable growth of multi-drug resistant bacteria has led to a major research effort to utilize alternative antibacterial therapeutics such as Photothermal therapy. It involves the use of photosensitizers in combination with visible light to produce heat that could kill pathogenic microorganisms. However, the precise accumulation of photosensitizer at infected site is still challenging. A new approach is developed to produce temperature induced localization of photosensitizer in staph infections.

Site-specific degradable stealthy nanoparticles for cancer treatment
The main reason of poor efficacy and adverse side effects of anticancer drugs is their non-specific distribution. Stealthy nanoparticles are employed to lessen non-specific distribution of drug. However, they hinder in specific interaction with tumor. Contrarily, targeting nanoparticles have been developed to enhance the interaction between nanoparticles and cancer cells. But, they are more vulnerable to non-specific distribution. The idea is to develop nanoparticles with stealthy layer; this layer protects nanoparticles from non-specific distribution, when nanoparticles arrive at cancer site, this layer is degraded due to cancer acidic environment and site-specific targeting layer is uncovered for binding to cancer cells.

Natural materials based composite matrix: an effective wound dressing for controlling hemorrhage and bacterial activities
This project is focused to develop chitosan based wound dressing with enhanced hemorrhage controlling and bacterial characteristics. For this, composite matrix, composed of three natural biomaterials, will be prepared. These three components possess distinct characteristics i.e. they have wound healing and film forming properties, strong adsorption tendency for bacterial stains and toxins, and antimicrobial property especially against bacterial infections. The interactions between different components and synergistic effect of matrix will be evaluated. Moreover, the microstructure of wound dressing will be designed in a way to mimic extracellular matrix of tissues.


Journal Papers:
1. Anam Shahzadi, Fakhera Ikram, Riaz ul Haq Subhani, Arsalan Ahmed, Anila Asif, Nighat Fatima, Aqif Anwar Chaudhry, Yong Hu (2019), "Acid susceptible polymeric stealthy nanoparticles for improved anticancer drug delivery", International Journal of Polymeric Materials and Polymeric Biomaterials, Impact Factor: 2.263   
2. Muhammad Usman Munir, Ayesha Ihsan, Ibrahim Javed, Tayyab Ansari, Sadia Z. Bajwa, Syed Nasir Abbas Bukhari, Arsalan Ahmed, M. Zubair Malik and Waheed S. Khan (2019), "Controllably Biodegradable Hydroxyapatite Nanostructures for Cefazolin Delivery against Antibacterial Resistance", ACS Omega, pp: 7524-7532, Vol: 4, Impact Factor: 2.584   
3. Wei Jiang, Chao Zhang, Arsalan Ahmed, Yunlei Zhao, Yu Deng, Yin Ding, Jianfeng Cai and Yong Hu (2019), "H2O2-Sensitive Upconversion Nanocluster Bomb for Tri-Mode Imaging-Guided Photodynamic Therapy in Deep Tumor Tissue", Advanced Healthcare Materials, Impact Factor: 6.270   
4. Muhammad Farrukh Nisar, Junwei He, Arsalan Ahmed, Youxin Yang, Mingxi Li and Chunpeng Wan (2018), "Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature", Molecules, pp: 2567, Vol: 23, Impact Factor: 3.06   
5. Peipei Xu, Huaqin Zuo, Bing Chen, Ruju Wang, Arsalan Ahmed, Yong Hu, and Jian Ouyang (2017), "Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma", Scientific Reports, Vol: 7, Standard: 2045-2322 (online), Impact Factor: 5.228    (External URL)
6. Arsalan Ahmed, Chao Zhang, Jian Guo, Yong Hu, Xiqun Jiang (2015), "Fabrication and characterization of Gd-DTPA loaded Chitosan-Poly(acrylic acid) nanoparticles for Magnetic Resonance Imaging", Macromolecular Bioscience, pp: 1105-1114, Vol: 15, Issue: 8, Standard: 1616-5187 (print) 1616-5195 (online), Impact Factor: 3.680    (External URL)
7. Arsalan Ahmed, Sen Liu, Yutong Pan, Shanmei Yuan, Jian He, Yong Hu (2014), "Multicomponent polymeric nanoparticles enhancing the intracellular drug release in cancer cells", ACS Applied Materials and Interfaces, pp: 21316-21324, Vol: 6, Issue: 23, Standard: 1944-8244 (Print) 1944-8252 (Web), Impact Factor: 7.145    (External URL)
8. Arsalan Ahmed, Hongliang yu, Dingwang Han, Jingwei Rao, Yin Ding, Yong Hu (2014), "Spatiotemporally programmable surface engineered nanoparticles for effective anticancer drug delivery", Macromolecular Bioscience, pp: 1652-1662, Vol: 14, Issue: 11, Standard: 1616-5187 (print) 1616-5195 (online), Impact Factor: 3.680    (External URL)
9. Arsalan Ahmed, Huanhuan Wang, Hongliang Yu, ZhengYang Zhou, Yin Ding, Yong Hu (2014), "Surface engineered cyclodextrin embedded polymeric nanoparticles through host-guest interaction used for drug delivery", Chemical Engineering Science, pp: 121-128, Vol: 125, Standard: 0009-2509, Impact Factor: 2.750    (External URL)


PhD (Materials Science)
Nanjing University, China
2011 to 2015
M.S (Materials & Surface Engineering)
National University of Sciences & Technology, Pakistan
2008 to 2010
B.S (Chemistry)
University of Sindh, Pakistan
2003 to 2006

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